ACADS

acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain
Identifiers
Symbol	ACADS
Entrez	35
HUGO	90
OMIM	606885
RefSeq	NM_000017
UniProt	P16219
Other data
EC number	1.3.99.2
Locus	Chr. 12 q24.31

ACADS (or SCAD) is a gene associated with short-chain acyl-coenzyme A dehydrogenase deficiency.^[1]

See also

Acyl CoA dehydrogenase

References

^ Tein I, Elpeleg O, Ben-Zeev B, et al (February 2008). "Short-chain acyl-CoA dehydrogenase gene mutation (c.319C>T) presents with clinical heterogeneity and is candidate founder mutation in individuals of Ashkenazi Jewish origin". Mol. Genet. Metab. 93 (2): 179–89. doi:10.1016/j.ymgme.2007.09.021. PMID 18054510. http://linkinghub.elsevier.com/retrieve/pii/S1096-7192(07)00417-9.

External links

GeneReviews/NCBI/NIH/UW entry on Short-Chain Acyl-CoA Dehydrogenase Deficiency

Oxidoreductases: CH-CH oxidoreductases (EC 1.3)

1.3.1: NAD/NADP acceptor	Enoyl-acyl carrier protein reductase/Enoyl ACP reductase · 7-Dehydrocholesterol reductase · Biliverdin reductase · 2,4 Dienoyl-CoA reductase

1.3.3: Oxygen acceptor	Dihydroorotate dehydrogenase · Coproporphyrinogen III oxidase · Protoporphyrinogen oxidase

1.3.5: Quinone	Succinate dehydrogenase (SDHA, SDHB, SDHC, SDHD)

1.3.99: Other acceptors	Fumarate reductase · Butyryl CoA dehydrogenase · Acyl CoA dehydrogenase (ACADSB, ACADS) · 5α-reductase (SRD5A1, SRD5A2, SRD5A3) · Glutaryl-CoA dehydrogenase · Isovaleryl coenzyme A dehydrogenase

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

Metabolism: lipid metabolism / fatty acid metabolism · triglyceride and fatty acid enzymes

Synthesis

Malonyl-CoA synthesis	ATP citrate lyase · Acetyl-CoA carboxylase

Fatty acid synthesis/ Fatty acid synthase	Beta-ketoacyl-ACP synthase · Β-Ketoacyl ACP reductase · 3-Hydroxyacyl ACP dehydrase · Enoyl ACP reductase

Fatty acid desaturases	Stearoyl-CoA_desaturase-1

Triacyl glycerol	Glycerol-3-phosphate dehydrogenase · Thiokinase

Carnitine palmitoyltransferase I · Carnitine-acylcarnitine translocase · Carnitine palmitoyltransferase II

General	Acyl CoA dehydrogenase (ACADL, ACADM, ACADS, ACADVL, ACADSB) · Enoyl-CoA hydratase MTP: HADH · HADHA · HADHB Acetyl-CoA C-acyltransferase

Unsaturated	Enoyl CoA isomerase · 2,4 Dienoyl-CoA reductase

Odd chain	Propionyl-CoA carboxylase

Other	Hydroxyacyl-Coenzyme A dehydrogenase

Malonyl-CoA decarboxylase

Long-chain-aldehyde dehydrogenase

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)